Anti-inflammatory effects of Rhizopus spp. fermentation products on ovalbumin-induced asthma in mice

Fermentation by Rhizopus spp. has been used as a traditional medicine for treating various inflammatory diseases. Allergic asthma is chronic respiratory disease that caused an exaggerated immune response. This study was conducted to ascertain the anti-inflammatory effects of fermentation extract (RU) on mouse model ovalbumin (OVA)-induced asthma. The animals were intraperitoneally injected OVA day 1 and 7, followed intranasal inhalation days 14 18. treated daily with RU (100 200 mg/kg) oral gavage from 18 23. significantly decreased eosinophilia production cytokines specific immunoglobulin E in asthma, along reducing airway inflammation mucus secretion lung tissue. Histological changes lungs levels mediators allergic evaluated. regulatory type 2 helper T (Th2) cell activation investigated. administration attenuated asthmatic such infiltration production, Th2-related cytokines, reduced Th2 activation. Administration effectively responses mice, which associated regulating differentiation. These results indicate can attenuate symptoms